Case Study: Development of a SPR Chip​

RPtag is our proprietary orally bioavailable protein binding scaffold. RPtag has two main parts, RPtag (large) and RPtag (small) that have a high binding affinity comparable to that of antibodies. RPtag is designed to be a vehicle for highly specific target delivery and identification, supported by its naturally occurring RBP derivative stability to temperature fluctuations, pH, and proteases. In the creation of RPtag, we developed a surface plasmon resonance (SPR) sensor to capture complexes as an arm of our integrated biochemistry and biophysics pipeline. Our technology allows for direct capture of targets directly from cell lysate and directly perform kinetic characterizations using analytes, subverting excessive handling in laboratory procedures. This method has the potential to enhance target solubility, expression yield, and purity; read more in our publication on RPtag (linked below).

At Ichor Discovery, our diligent focus prioritizes the service our clients receive. We are always looking for innovative ways to improve the efficiency of our internal processes and do not hesitate to take advantage of improved methodologies.