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Kinetics of the multitasking high-affinity Win binding site of WDR5 in restricted and unrestricted conditions (2021)
Using real-time binding measurements in a high-throughput setting, we identified the kinetic fingerprint of transient associations between WDR5 and 14-residue WDR5 interaction (Win) motif peptides of each SET1 protein (SET1Win).
We dissected the molecular differences between a weak and a strong SIRT6 protein and identified five amino acid residues that are fully responsible for their differential activities, demonstrating that DSB repair and SIRT6 have been optimized during the evolution of longevity.
Ichor Life Sciences Portfolio Company, Auctus Biologics, Awarded NSF Grant to Develop New SPR Chip Technology
Ichor Life Sciences Portfolio Company, Auctus Biologics, Awarded NSF Grant to Develop
Clarkson University Features Professor Aaron Wolfe for Publication in Leukemia Diagnostics
Ichor Life Sciences CSO Co-Authors Peer Reviewed Article in Nature Communications on Development of a Protein Nanopore for Detection of WDR5
ICHOR LIFE SCIENCES CSO CO-AUTHORS PEER-REVIEWED ARTICLE IN NATURE COMMUNICATIONS ON DEVELOPMENT