Biophysical

No project is too big or too small. We offer industry competitive pricing, unmatched turnaround times, and personalized project management with no cookie cutter solutions.

Surface Plasmon Resonance (SPR)

SPR is a high-throughput technique that measures the kinetics of biomolecular interactions, including those of fragments & small molecules. The Gold Standard of biophysics.

Isothermal Titration Calorimetry (ITC) & Differential Scanning Calorimetry (DSC)

ITC is a truly label-free, steady-state technique to directly determine the thermodynamic parameters of biomolecular interactions. An excellent orthogonal complement to SPR.

Bio-Layer Interferometry (BLI)

BLI is a high-throughput kinetic screening technique that can measure biomolecular interactions of proteins, peptides, and nucleic acids in complex matrices and without microfluidics.

Nuclear Magnetic Resonance (NMR)

NMR spectroscopy can be used for both biosimilar comparability & QC, in addition to fragment screening and affinity titration studies.

Plate-Based Assays

Ichor has the capability to conduct a variety of quantitative plate based assays, including ELISAs and various fluorescence experiments (e.g. FRET & anisotropy).

SPR is our speciality!

Assay development, high-throughput fragment and small molecule screening, & kinetic or affinity characterization

We have both Biacore 8K and 8K+ SPR systems, the state of the art

  • High-throughput SPR screening: kinetic screening & characterization
  • Clean, binding level, & affinity screens
  • Epitope binning
  • Concentration & potency analysis
  • Personal one on one discussion of data and results with a Ph.D. scientist; we stand by our data

Assay development & Target Validation: Feasibility and full control characterization

Fast turnaround, most projects are initiated within 1-2 weeks upon receipt of materials.

Full ownership, client retains full ownership of all raw and processed data and is entitled to Excel exports and a PowerPoint presentation of data and results.

Instrumentation

Discovery-North-2

We have invested heavily in facilities, state of the art capital equipment, and highly trained personnel so you don’t have to!

Biacore 8K & 8K+

Biacore 8K & 8K+ SPR systems

What’s better than a Biacore 8K? A Biacore 8K+!

BLI-6

ForteBio Octet RED384

Biomolecular interaction analysis without the microfluidics.

i3 plate reader image

Molecular Devices SpectraMax i3x

Our temperature controlled plate reader is equipped with an automated high-throughput StakMax and can work with 96- or 384-well plates in absorbance, fluorescence, or chemiluminescent read modes.

ITC

TA Instruments nano-ITC & nano-DSC

The nano-series instruments only require a fraction of the protein quantity that earlier models consumed.

Bruker 800_2

Bruker AVANCE III HD 800 MHz with TCI Cryoprobe

Whether you are looking for biosimilarity comparisons, high-throughput fragment screening, isotopically enriched protein production, or NMR consultants; we have what you are looking for!

Testimonials

Client satisfaction is our measure of success

Ankyra logo

“Ichor helped us develop a custom binding assay that was critical for selection and optimization of our lead molecule. Throughout the process, the Ichor team was highly collaborative and flexible and provided high quality data in a timely manner”

– Ankyra Therapeutics

Our biophysics projects have fast turnaround times

Most biophysics projects start within 2 weeks of receipt of materials.

FAQs

Please reach out to us with any questions or comments, we are here to help you.

All projects are managed by PhD level scientists and most projects start within 1-2 weeks of receipt of all test articles, samples, reagents, and consumables. We take pride in our work and pay attention to details during the execution. At the conclusion of your project, all data and reagents are yours. You can expect to receive a PowerPoint slide deck containing all relevant conditions and data as a project deliverable, in addition to all raw data.

Our view of customer service demands that all projects receive the dedicated attention, research, and scoping they deserve to be properly and fully quoted and executed at the highest scientific standards. We also believe in being respectful of everyone’s time. We therefore require all prospective clients to attend a brief teleconference to discuss their projects before a quote can be issued. Out quotes are custom-built and tailored to your specific project.

No project is too small for us. We are here to help solve your problems and we see ourselves as your lab down the hall.

We publish our own research:

SPR-pub-1

Kinetics of the multitasking high-affinity Win binding site of WDR5 in restricted and unrestricted conditions

Pub-3

Convergent Alterations of a Protein Hub Produce Divergent Effects within a Binding Site

pub_2

Interplay of Affinity and Surface Tethering in Protein Recognition

pub4

RPtag as an Orally Bioavailable, Hyperstable Epitope Tag and Generalizable Protein Binding Scaffold

We develop our own tools:

SPR

SBIR Phase I:

Development of an Optical Biosensor to Facilitate Screening, Validation, and Development of Novel Drugs and their Biological Targets

RPtag Capture:

NSF Award # 2129469 via Ichor portfolio company, Auctus Biologics, Inc.