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Preclinical Toxicology Studies
Ichor Life Sciences provides a range of preclinical toxicology study designs and services to support your drug development and IND-submission needs. Our detail-oriented and highly skilled technical and study direction teams are dedicated to partnering with you for the best quality study.
Our Toxicology Services
Acute Toxicity Studies
Establish the maximum tolerated dose (MTD) level of your test compound in a novel species, as well as identify potential adverse effects and determine dose levels for future studies.
Dose-Range Finding Studies
Dose-range finding (DRF) studies are important to conduct prior to the definitive GLP studies to assess potential adverse effects and determine tolerable dose levels. We offer single and repeat-dose designs.
Carcinogenicity Studies
Discover the potential tumorigenicity of your long-term use compound. Ichor has extensive experience in both life-span studies and carcinogenic models, creating the perfect blend of knowledge and skills.
Chronic/Subchronic Toxicity
With Ichor’s team of life-span study experts, we are ready to provide you with comprehensive data to inform decisions regarding the safety of your test compound after long-term exposure in subchronic and chronic studies.
Ocular Toxicity
Let our team of specialists demonstrate why we’re one of the fastest growing preferred partners in ophthalmology! With capabilities in ocular dose administration and a wide variety of techniques, we’re ready to deliver high quality results.
Routes of Administration
- Oral Gavage
- Intraperitoneal
- Intravenous (bolus, slow push, retro-orbital)
- Intramuscular
- Subcutaneous
- Ocular (intravitreal, subretinal, intracameral, and suprachoroidal)
- Topical/Dermal
- Inhalation
- Intracranial ventricular
- Intranasal
- Dietary
- Vaginal/Anal
Investigative Studies
Our preclinical toxicology research team is ready to help you further investigate the tolerability and toxicity of your compound. By partnering with Ichor Life Sciences, you’re choosing a capable and dedicated team to help with your investigative and nonGLP studies allowing you to enter larger-scale projects with confidence.
Model Highlight
Our team is quickly becoming the most preferred partner for ocular studies. We offer a variety of validated preclinical models, ocular PK/PD services, and utilize the industry-best equipment to conduct our studies. We offer tonometry (IOP) evaluation, electroretinography (ERG), enhanced microscopic evaluation, ocular histopathology, ocular and systemic tissue distribution services, and more.
Capabilities and Services Summary
High Animal Welfare Standards
Our technical and veterinary team adhere to the highest standards for animal care and welfare. Not only is our vivarium an AAALAC accredited facility with an in-house IACUC, but our team goes the extra mile to give the animals the best level of care. We have a robust positive reinforcement training program as well as industry-leading housing and enrichment standards.
In-House Capabilities
Ichor serves as a one-stop-shop for many in vivo study needs, and we use the most state-of-the-art equipment for the work we perform. Our team can assess neurobehavioral endpoints, perform almost every blood collection or dosing technique, as well as a myriad of ophthalmology techniques, and more. You can be confident you’re getting the best there is to offer.
Experts in the Unconventional
Ichor is your ideal partner for unconventional ideas and studies. Before spending exorbitant amounts of money on a GLP study, consider partnering with our team to run a DRF or exploratory study so you can begin your large-scale GLP studies with confidence.
Frequently Asked Questions
Answers to some of the most common questions about preclinical toxicity research.
We currently offer the following designs (nonGLP):
- Dose Range Finding single and repeat dose studies
- PK/TK studies
- Repeat and single dose studies
- Chronic and subchronic studies
- Ocular studies
- Carcinogenicity studies
- DRF-Embryo-fetal development (SEGII) studies
- LD50 designs
- DRF Juvenile toxicity
- Exploratory/Investigative toxicology]
Although not currently providing GLP studies, Ichor Life Sciences has partnered with numerous clients in providing exploratory and nonGLP carcinogenicity studies in order to provide you with the confidence you need when moving into your large-scale GLP study.
Ichor has extensive experience with mouse, rat, rabbit, and swine studies. We also regularly work with specialty strains of mice and rat, depending on client needs.
Every FDA submission varies depending on the compound type, intended patient population, and therapeutic index. Our team can help you determine what might be best for your compound.