Using differential scanning calorimetry (DSC) - TA Instruments Nano DCS
- Protein stability
- Thermodynamics studies
What is ITC & DSC
Competitive Binding Experiments
Overview of the design and execution of competitive inhibitor experiments via ITC, with particular relevance to fragment screening.
Obtaining Enzyme Kinetics with ITC
Application Note for using ITC to obtain enzyme kinetic constants.
Related Products & Services:
ITC is an excellent secondary or orthogonal screen for hit validation and characterization, but a technique such as SPR is recommended for primary and high-throughput screening.
High-Throughput Primary Screening via SPR
SPR Services for High-Throughput Fragment Screening & Hit Validation
Fragment clean screens, binding level screens, & titrations for binding confirmation and kinetics.