Spanning anterior to posterior disease models, we can assist! Our core business has been rooted in ophthalmic pharmacology for over 10-years. Our scientific staff is standing by to assist with developing your investigational product.

Glaucoma Models

Leverage our experience and proficiency in glaucoma animal models to meet the development needs of your investigational products and research programs.

Uveitis Models

Evaluate your investigational product using our established experimental autoimmune uveitis (EAU) and endotoxin-induced uveitis (EIU) models.

Age-Related Macular Degeneration (AMD) Models

We offer a variety of validated pre-clinical models for wet and dry age-related macular degeneration and Stargardt’s disease.

Custom Models

We work collaboratively with our clients to develop and validate new models and analytical endpoints.

Ocular PK/PD Services

Perform ocular PK/PD studies in a variety of species spanning anterior or posterior applications.

Featured Capabilities

Our preclinical ophthalmic research team utilizes industry-best equipment to conduct studies. Quality equipment for quality results.

Track retinal disease progression using superior image quality with SD-OCT. More accurate measurements means clearer characterization of pathogenesis in our disease models.

Obtain high definition images in anterior and posterior segment disease models to better inform pathogenesis and therapeutic response. Our automated scoring algorithms provide robust, quantitative read-outs.

Microinfusion pumps and micromanipulator devices for rodents provide accurate, efficient, and proficient drug delivery. Available administration modalities include intravitreal, subretinal, intracameral, suprachoroidal, and topical.

We perform complex dissection for all ocular tissues. From flat-mounts to whole eye collections, we provide H&E, IHC, and IF processing, flow cytometry, ELISA, western-blot, and mass spectrometry.

Evaluate the preservation or restoration of ocular function with high quality ERGs. This powerful technique tests retinal function in response to electrical impulses.

We provide clear and consistent fluorescent angiograms and fundus autofluorescence measurements for a variety of different ocular models. Quantitation using automated scoring is also available.

IOP measurements can be compromised by external effects, leading to false readings. Our positive reinforcement training (PRT) ensures study animals are stress free to provide reliability and consistency in our measurements.

Your Results Await

feat model

This featured Stargardt disease research model utilizes the ABCA4-/- transgenic knockout mouse for testing gene therapy and other investigational products for Stargardt disease and dry age-related macular degeneration. Blue light illumination in the ABCA4-/- strain activates reactive lipofuscin fluorophores and induces retinal lesions, which can be measured by fundus imaging, OCT, and histology. Functional impairment by ERG is also observed. This model is ideal for interventions aimed at directly or indirectly reducing lipofuscin burden or cytoprotective interventions intended to preserve RPE and photoreceptor structure and function.

Endpoints with Goals in Mind

6220_Laser CNV_Day 14

Advanced Imaging in CNV Model

We utilize state-of-the-art imaging modalities to provide the most robust data sets in support of client projects. If a picture is worth 1,000 words our data speaks volumes.


Histology for Target Engagement

We do not stop just at efficacy endpoints. Confirmation of target engagement and a clear understanding of mechanism of action inform downstream product development.

Capabilities and Services Summary

Facilities and Animal Welfare

Facilities and Animal Wellness 


Our vivarium is an AAALAC accredited facility that supports rapid protocol review. We are an independent company with 100% of our operations in the United States. Consistent with a strong ethos towards animal welfare, our positive reinforcement training (PRT) program and enrichment standards are world class and industry-leading.




Ichor uses the most state-of-the-art equipment in the field of ophthalmology. This includes the Leica spectral-domain optical coherence tomography (OCT), Phoenix Micron IV, TonoPen and TonoLab, and World Precision Instrument’s microinfusion pump system for intraocular drug delivery. The advantage of using the Leica OCT allows for more accurate scans in rodent models, precise retinal thickness measurements, and high-quality resolution images of retinal architecture. With the Phoenix Micron IV, we can perform fundoscopy, fundus autofluorescence, fluorescein angiography, anterior imaging, blue light illumination exposure. In combination with our IOP readings with our tonometers we implement the use of positive reinforcement training to allow for conscious-anesthesia free IOP measurements. Full field ERGs are also available upon request. The use of WPI’s microinfusion injection equipment allows for accurate and reproducible intraocular injection procedures allowing us to complete intravitreal, subretinal, intracameral, and suprachoroidal injections.

An Image Worth 1,000 Words

An Image Worth 1,000 Words


We understand that decisions are made every day based on the data we produce, and we recognize the responsibility to deliver on our clients’ trust in us. Whether it be OCT scans to inform a winner amongst multiple lead candidates, or vibrant histology slides stained in your company’s colors to wow investors, we are firmly committed to providing the highest quality data possible for your needs.

We Are Always Evolving

We Are Always Evolving


Our preclinical ophthalmic research team members regularly attend scientific conferences to keep up to date with the latest models, instrumentation, and therapeutic targets. We partner with technology companies developing next generation analytical instrumentation and biomarkers to always be on the forefront of industrial trends and client needs.

From studies to programs, we support preclinical ophthalmic research.

Accelerate your ophthalmology research by speaking with our experts.

Frequently Asked Questions

Answers to some of the most common questions about preclinical ophthalmic research service offerings.

In vivo models allow for the assessment of investigational product safety and efficacy before moving into human clinical trials. In vivo models can also be used to study the onset and progression of a disease state in a living organism.

We offer in vivo models for most common ocular disorders. Looking for something uncommon? We can partner with your organization to onboard and validate new or rare in vivo models to support your preclinical ophthalmic research program.

Yes. In vivo models enable the testing of therapeutics for a wide variety of different properties, including safety and efficacy as well as pharmacokinetic and pharmacodynamic properties.