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Uveitis Models
Leverage our expertise in ocular disease, uveitis animal models and immunology to advance your uveitis research programs.
Evaluate your investigational product using our established Experimental Autoimmune Uveitis (EAU) and Endotoxin-Induced Uveitis (EIU) models. Does your program require custom solutions? Inquire about our custom services.
Featured Capabilities
Our veterinary ophthalmology team supports uveitis research studies with a variety of solutions for clients.
Using the MICRON ® IV, anterior segments capture progression of disease and provide in-life disease scoring.
Our staff is proficient and accurate in the delivery of topical treatments.
Aqueous humor samples can be collected at the conclusion of the study to test for inflammatory markers or other targets of interest.
Fundus images of each injection procedure provide confirmation that treatment was delivered properly.
Both EAU and EIU can use H&E staining for clinical scoring. IF/IHC can be added for validation of target engagement and similar applications. Custom panels are available.
Uveitis Model Clinical Scoring
Endotoxin-Induced Uveitis (EIU) Model
This figure shows representative clinical pathology scoring of the EIU model. Uveitis in this model is attenuated by administration of a steroid.
Experimental Autoimmune Uveitis (EAU) Model
This graph illustrates the ability of IRBP+CFA to induce uveitis and FTY-720 suppressing the inflammatory response. Here we show that delivery of LPS is just as effective at disease induction as systemic foot-pad injections.