Skip to content
Toxicity Testing
Performing a dose range finding study followed by toxicity testing are critical components of a successful drug development pipeline. Learn more about how Ichor Life Sciences can support your project during this crucial stage!
We offer full-service dose range finding and toxicity study testing from discovery to pivotal IND-enabling workflows.
Dose Range Finding Study
Ichor will help you identify the appropriate dosing regime to ensure smooth progress through regulatory submission.
Acute Toxicity Testing
Short and simple toxicity testing reveals potential adverse events and unexpected findings early in your pipeline.
Repeat Dose Tox
Sustained administration of compounds over time more accurately reflects clinical application and will help predict results in humans.
Toxicity Testing for Confident Drug Development
Toxicity testing is a critical component of preclinical drug development, providing essential insight into the safety, tolerability, and potential adverse effects of a therapeutic candidate before advancing into clinical development. Our toxicity testing services are designed to help sponsors evaluate safety profiles across a range of therapeutic modalities while generating high-quality data to support informed development decisions. Through carefully designed in vivo studies, toxicity testing can help characterize dose-related effects, identify potential target organ toxicities, establish exposure and tolerability relationships, and determine appropriate dose levels for subsequent studies. Study designs can incorporate relevant clinical observations, body weight and food consumption monitoring, clinical pathology, bioanalysis, necropsy, organ weights, histopathology, and other endpoints based on program objectives. By integrating toxicity testing into a broader preclinical development strategy, sponsors can identify potential safety concerns earlier, refine dosing strategies, and better understand the relationship between pharmacologic activity, systemic exposure, and adverse effects. Whether supporting early candidate selection, dose-range finding, repeat-dose evaluation, or later-stage development planning, our toxicity testing capabilities provide the scientific rigor and flexibility needed to move promising therapeutic programs forward with greater confidence.
Capabilities and Services Summary
High Animal Welfare Standard
Our technical and veterinary team adhere to the highest standards for animal care and welfare. Not only is our vivarium an AAALAC accredited facility with an in-house IACUC, but our team goes the extra mile to give the animals the best level of care. We have a robust positive reinforcement training program as well as industry-leading housing and enrichment standards.
In-House Capabilities
Ichor serves as a one-stop-shop for many in vivo study needs, and we use the most state-of-the-art equipment for the work we perform. Our team can assess neurobehavioral endpoints, perform almost every blood collection or dosing technique, as well as a myriad of ophthalmology techniques, and more. You can be confident you’re getting the best there is to offer.
Experts in the Unconventional
Ichor is your ideal partner for unconventional ideas and studies. Before spending exorbitant amounts of money on a GLP study, consider partnering with our team to run a DRF or exploratory study so you can begin your large-scale GLP studies with confidence.
Frequently Asked Questions
Optimal preclinical study design is essential for successful drug development. Let our vast experience guide your thinking.