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Cancer Models
Discover our extensive collection of cancer models, encompassing oncology mouse models and immuno-oncology models tailored to support your research. We provide syngeneic, orthotopic, and xenograft cancer models, supporting both standardized and customized options to suit your specific needs.
Our expert scientists will assist you throughout the entire process, from conceptualization and design, to execution and data analysis. Our comprehensive oncology, and immuno-oncology models will accelerate drug development, and enable you to progress toward successful clinical trials through making informed decisions.
Exclusive Chemotherapy Resistant Models
Chemotherapy resistance limits the use of chemotherapeutic drugs in cancer treatment. We offer a variety of chemo resistant cancer mouse models to test out strategies to overcome these resistant mechanisms.
Customized Model
Our team of experts can work with your team to create oncology or immuno-oncology models that are suited to your needs.
Types of Cancer Models Available
Syngeneic cancer models utilize immunocompetent mice with the original tumor strain in order to study immunology as a form of cancer therapy, we provide a broad range of immuno-oncology models such as:
- PDAC Mouse Tumor Model
- Lewis Lung Carcinoma Mouse Model
- CT-26 Mouse Tumor Model
- T1 Mouse Model
- B16-F10 Mouse Tumor Model
- Renca Mouse Model
- EMT6 Mouse Tumor Model
Xenograft cancer mouse models do not replicate the native microenvironment of tumors, unlike orthotopic models, however they accept a wider range of human cell lines, and better replicate the immune response of humans against cancer.
Breast Cancer: MCF7 (Luc) cell line
Colon Cancer: HCT116 and MC38 cell line
Pancreatic Cancer: Panc-1 and Panc-10.05 cell lines
Melanoma: A375 and SK-MEL-28 cell lines
Leukemia: AML (Kg-1a) cell line
Orthotopic cancer models are used as a platform for preclinical studies and drug development, because of its ability to mimic the physiological environment of human tumors more accurately than other models. We are able to provide a broad range of orthotopic oncology mouse models such as:
PDAC (Pancreatic Ductal Adenocarcinoma)
LL/2 (Lewis Lung Carcinoma)
CT-26 (Colon Carcinoma)
B16-F10 (Melanoma)
Renca (Renal Cell Carcinoma)
EMT6 (Breast Carcinoma)
Applications of Oncology Models in Cancer Research
Within the field of cancer research, oncology mouse models, including immuno-oncology models, have a wide range of applications that contribute to the understanding of cancer biology, and are crucial in the development of new therapies. These models have various key applications in research, including:
Preclinical Testing & Drug Development: Primary applications of cancer models include the assessment of the safety and efficacy of new drugs. These models are utilized for preclinical testing, and generating data that supports decision-making in progressing drug candidates to clinical trials as part of drug development.
Researching Immunotherapies: Cancer treatment has experienced groundbreaking approaches with the emergence of immunotherapies, by studying the immune system’s interaction with tumors and its response to immunotherapeutic agents, immuno-oncology models play a vital role in immunotherapy research. Through these studies, we can design more effective immunotherapies that harness the body’s immune defences to combat cancer.
Mechanisms of Tumor Biology and Progression: Understanding tumor biology and progression in cancer is crucial for the development of effective drug candidates, this requires the use of cancer models, which allow investigation of cellular and molecular mechanisms that are fundamental to tumor initiation, growth, metastasis, drug resistance. In turn, this knowledge helps to develop targeted therapies, optimization of treatments, and improve patient outcomes.
Personalized Medicine: Tailor and develop targeted therapies with our cancer models. With the ability to base therapies on unique characteristics, genomic profiling, and drug sensitivity of patient-derived models, these models aid in identifying effective treatments and predictive biomarkers.
Metastasis Studies: Metastasis is a major cause of cancer related mortality, oncology mouse models are key to the study of the mechanism and factors that are involved in cancer cell migration, invasion, and tumor settlement at distant sites. Cancer mouse models can therefore be used to study and provide insights for potential targeted therapies to fight against metastasis.
Our pharmacokinetics (PK) and pharmacodynamics (PD) services for immuno-oncology aim to expedite the advancement of immunotherapies. Through optimizing PK and PD within immuno-oncology models, cancer treatment outcomes can be improved. To effectively leverage these immuno-oncology models, a thorough understanding of drug dynamics and their impact on the immune system is required.
Pharmacokinetics (PK)
PK studies investigate the interaction between the administered substance and the human body. It aids in examining the movement of these substances throughout the body, encompassing process such as absorption, distribution, metabolism, and elimination (ADME).
Pharmacodynamics (PD)
Studying the pharmacodynamics of drug and substances in immuno-oncology models helps us understand their interaction with living organisms. These studies analyze the drug’s impact on receptors, enzymes, and cellular pathways within immuno-oncology models.
Supportive Services for Cancer and Oncology Mouse Models
We offer a range of services that complement our cancer and oncology models, giving you access to enhanced studies and detailed results: