Orthotopic Models

Benefits of the Orthotopic Mouse Model

  1. Natural tumor microenvironment: Through replicating natural conditions, including tissue-specific factors, blood supply, and interaction with neighboring cells, the orthotopic mouse model will enable the observation of tumor behavior in a context that closely resembles clinical scenarios.
  2. Clinical Relevance: By studying tumors in their native environment, your research findings can gain enhanced clinical relevance, orthotopic mouse models provide valuable insights that bridge the gap between preclinical studies and human clinical trials, accelerating the development of effective therapies.
  3. Interaction with the immune system: Heavily influenced by critical tumor-immune interactions, cancer development and treatment response can be investigated with the orthotopic mouse model.

Advancing Cancer Research In Vivo with the Orthotopic Mouse Model

Many varieties of the orthotopic mouse model have proved highly valuable in advancing the understanding of various cancers, some examples of in vivo studies with orthotopic mouse models include:

Breast Cancer: Extensively used in breast cancer research, the orthotopic mouse model enables the study of metastatic behavior of breast cancer tumor cells. Because the model is able to closely mimic the natural tumor microenvironment of the cancer, it facilitates the investigation of tumor growth, metastasis, and response to treatments, including chemotherapy, radiation, and targeted therapies.

Brain Cancer: The malignant brain tumor, Glioblastoma Multiforme, has been thoroughly studied via the orthotopic mouse model, in exploring tumor progression, invasion of surrounding regions, and for understanding the role of blood-brain barrier in drug delivery. These studies provide crucial knowledge for developing effective treatments in order to combat this complex disease.

Pancreatic Cancer: Utilized in studying this aggressive disease, and in evaluating its tumor progression, invasion, and therapeutic responses, the mouse model can be used to identify biomarkers, and novel treatment strategies for pancreatic cancer.

Prostate Cancer: The orthotopic mouse model has been used to study the interactions of prostate cancer cells with its surrounding tissue, in order to study tumor growth, metastasis, and hormone responsiveness, through this new therapies can be tested, such as androgen deprivation treatments.

Lung Cancer: Orthotopic mouse models facilitate the study of lung cancer, its metastasis, and the effects of therapies and immunotherapies on targeted tumor cells, by implanting lung tumor cells into the lungs of mice.

Colorectal Cancer: Using the orthotopic mouse model, the interaction between colorectal cancer and the intestinal environment can be closely studied, evaluating tumor growth, invasion, and response to therapeutic agents like chemotherapeutics and immunotherapies.

A Sample of Orthotopic Models Offered

Ask us if you are looking for a specific orthotopic mouse model! We’ll help you onboard your model.

PDAC Mouse Model: UNKC06141

The UNKC6141 Orthotopic mouse model is useful in understanding pancreatic ductal adenocarcinoma progression, metastasis, and heterogeneity.

B16-F10 Mouse Model

B16-F10 is used in both syngeneic and immunocompromised models, and is useful in studying tumor regression in melanoma models.

Lewis Lung Carcinoma Mouse Model: LL/2

The LL/2 mouse model serves in generating applicable syngeneic tumor characterization of immunotherapies that can be beneficial to lung cancer.

Renca Mouse Model

Renca is a mouse renal adrenocarcinoma cell line that is used in generating syngeneic models. It’s characteristics make a prime model for studies on angiogeneisis and immune checkpoint inhibitors such as PD-1.

CT-26 Mouse Model

A colon cancer mouse model derived from BALB/C mice, this cancer model is useful for murine solid tumors and immunogenic tumor models for colorectal cancer.

EMT6 Mouse Model

The EMT6 mouse model can be used as a powerful immune-oncology tool due to the favorable immune profile and responsiveness it has to immune checkpoint blockades.

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