Orthotopic Mouse Models | Ichor Life Sciences

Orthotopic oncology mouse models help researchers understand cancer development, progression, and treatment efficacy in a more accurate way than other models. They are particularly relevant for hard-to-treat cancers, such as pancreatic cancer and glioblastoma.

Monitoring tumor progression with flow cytometry panels

Flow cytometry panels can allow for monitoring of tumor growth and metastasis in orthotopic mouse models. This can provide insights into the efficacy of potential therapies and identify potential biomarkers for response or resistance to treatment.

Histology and immunohistochemistry

Tumor tissues from orthotopic models can be analyzed using histological techniques to examine changes in tissue architecture, cell morphology, and protein expression, providing insights into the biological effects of treatments.

Imaging

Non-invasive imaging techniques such as bioluminescence can be used to monitor tumor growth and metastasis in real-time, providing insights into the efficacy of treatments and identifying potential biomarkers for response or resistance.

Pharmacokinetic and pharmacodynamic studies

Orthotopic models can be used to study the pharmacokinetics and pharmacodynamics of potential therapies, including drug distribution, metabolism, and toxicity.

A Sample of Orthotopic Models Offered

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PDAC Mouse Model: UNKC06141

The UNKC6141 model is useful in understanding pancreatic ductal adenocarcinoma progression, metastasis and heterogeneity.

B16-F10 Mouse Model

B16-F10 is used in both syngeneic and immunocompromised models and is useful in studying tumor regression in melanoma models.

Lewis Lung Carcinoma Mouse Model: LL/2

The LL/2 mouse model serves in generating applicable syngeneic tumor characterization of immunotherapies that can be beneficial to lung cancer.

Renca Mouse Model

Renca is a mouse renal adenocarcinoma cell line that is used in generating syngeneic models, its characteristics make it a prime model for studies on angiogenesis and immune checkpoint inhibitors such as PD-1.

CT-26 Mouse Model

A colon cancer mouse model derived from BALB/c mice, this model is useful for murine solid tumors and immunogenic tumor models for colorectal cancer.

EMT6 Mouse Model

The EMT6 mouse model can be used as a powerful immuno-oncology tool due to the favorable immune profile and responsiveness to immune checkpoint blockades.

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Orthotopic Models