Orthotopic Models

Orthotopic oncology mouse models help researchers understand cancer development, progression, and treatment efficacy in a more accurate way than other models. They are particularly relevant for hard-to-treat cancers, such as pancreatic cancer and glioblastoma.

A Sample of Orthotopic Models Offered

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PDAC Mouse Model: UNKC06141

The UNKC6141 model is useful in understanding pancreatic ductal adenocarcinoma progression, metastasis and heterogeneity.

B16-F10 Mouse Model

B16-F10 is used in both syngeneic and immunocompromised models and is useful in studying tumor regression in melanoma models.

Lewis Lung Carcinoma Mouse Model: LL/2

The LL/2 mouse model serves in generating applicable syngeneic tumor characterization of immunotherapies that can be beneficial to lung cancer.

Renca Mouse Model

Renca is a mouse renal adenocarcinoma cell line that is used in generating syngeneic models, its characteristics make it a prime model for studies on angiogenesis and immune checkpoint inhibitors such as PD-1.

CT-26 Mouse Model

A colon cancer mouse model derived from BALB/c mice, this model is useful for murine solid tumors and immunogenic tumor models for colorectal cancer.

EMT6 Mouse Model

The EMT6 mouse model can be used as a powerful immuno-oncology tool due to the favorable immune profile and responsiveness to immune checkpoint blockades.

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