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PDAC Mouse Model: UNKC-6141
Pancreatic cancer is one of the most lethal forms of cancer with pancreatic ductal adenocarcinoma (PDAC) as the most common form. UNKC-6141 is a mouse pancreatic ductal adenocarcinoma cell line positive for KRAS and ductal marker CK19 making it a valuable model for examining diagnostic markers and therapeutic drug discovery.
We have characterized UNKC-6141 mouse of pancreatic ductal adenocarcinoma expressed as a flank model in C57BL/6 mice for analyzing the efficacy of therapies for pancreatic cancer. The genetic profile of UNKC-6141 cells mimics the natural progression of PDAC in human mutagenesis.
Fast Growing and Reproducible
The UNKC-6141 cell line displays aggressive growth in syngenetic models allowing for efficient analysis of therapeutic agents.
Aggressive Growth
The UNKC-6141 cell line has metastatic potential spreading to the liver, spleen, small intestines, and lymph nodes.
Immune Response and Treatments
The UNKC-6141 syngenetic mouse models provides a sufficient immunocompetent setting to study cell infiltration and effectiveness of immunotherapies.
Pancreatic Ductal Carcinoma Mouse Model
Commonly Requested Endpoints
Histopathology
Our customizable histopathological analysis can help evaluate tumor microenvironments, track tumor progression and metastases and inform treatment decisions.
Flow Cytometry
Our flow cytometry expertise can help characterize tumor-infiltration T lymphocytes, identity immune biomarkers, and so much more.