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STZ HFD Mouse Model
Streptozotocin (STZ) and high-fat diet (HFD) challenges create a model of the “two-hit” hypothesis of NASH - insulin resistance leads to steatosis which combines with inflammation and other stressors to produce steatohepatitis.
Let the team at Ichor design and execute this translatable model tailored to your specific research needs.
STZ challenge in neonatal or adult animals (mice or rats) disrupts normal insulin production leading to a prediabetic/diabetic phenotype. The subsequent challenge of a high fat diet combines with hyperglycemia to reproduce common trends observed in human disease progression, ultimately resulting in steatosis and fibrosis.
Highly Customizable
Successfully produce data in mice and rats, male and female animals, neonates or adults, with a diabetic phenotype tuned to fit your needs.
NASH Phenotype in 8-12 weeks
Depending on model conditions, NASH phenotypes emerge by 8-12 weeks with progression to HCC thereafter.