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Friedman Model
The Friedman model of non-alcoholic steatohepatitis (NASH) was first described in 2019 as a method to produce extensive liver fibrosis for preclinical drug testing. The team at Ichor has the technical and animal care expertise required to produce highly informative results using this model.
The Friedman model produces a robust NASH phenotype through the combination of dietary and chemical insults. A Western Diet, high in fat, fructose, and cholesterol is accelerated by the addition of low dose CCl4 to produce fibrosis with progression to hepatocellular carcinoma (HCC). The model provides an ideal tool for the efficacy assessment of therapeutic compounds to treat NASH.
Save Time Over Diet-Only Models
Diet-only NAFLD/NASH models may take up to one full year to develop. The Friedman model greatly accelerates the time to meaningful results.
Highly Translatable
The molecular, histological, and immunological characteristics produced by the Friedman model are closely aligned with those observed in human disease.
Reliable Progression to HCC
In a highly reproducible manner, the NASH phenotype will culminate in HCC given sufficient duration (~24 weeks) on HFD and CCl4.