STZ challenge in neonatal or adult animals (mice or rats) disrupts normal insulin production leading to a prediabetic/diabetic phenotype. The subsequent challenge of a high fat diet combines with hyperglycemia to reproduce common trends observed in human disease progression, ultimately resulting in steatosis and fibrosis.
Successfully produce data in mice and rats, male and female animals, neonates or adults, with a diabetic phenotype tuned to fit your needs.
NASH Phenotype in 8-12 weeks
Depending on model conditions, NASH phenotypes emerge by 8-12 weeks with progression to HCC thereafter.