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NASH Models
Nonalcoholic steatohepatitis (NASH) stands as the most advanced stage of non-alcoholic fatty liver disease (NAFLD), our NASH mouse model closely replicates human NASH characteristics, offering a valuable platform for your study. Let our experienced team assist your research in the pathology, mechanisms, and potential treatments using our NASH mouse model.
Non-Alcoholic Steatohepatitis (NASH)
Due to its progressive nature, NASH, if not managed carefully, can result in severe liver complications, such as hepatocellular necrosis and fibrotic depositions. NASH is typically characterized by inflammation, fat accumulation, and liver cell damage.
More than one-quarter of the global population is estimated to be affected by NAFLD; however, the prevalence of NASH is approximated to be at least 3-5%. As obesity and metabolic disorders continue to increase globally, NAFLD/NASH rates are projected to rise as well, increasing the rates of hepatocellular carcinoma (HCC).
Development of reliable and translatable models for researching the drivers of NASH, along with gauging the effectiveness of new pharmaceutical compounds is becoming increasingly crucial, the NASH mouse model provides help in investigating NASH.
What is the NASH Mouse Model?
The NASH mouse model is curated model that mimics the key features of NASH, as observed in humans, because the NASH mouse model is specifically designed to replicate the complex pathophysiology of NASH, it also includes the accumulation of fat in the liver, inflammation, oxidative stress, and eventual progression to fibrosis.
In preclinical research, the NASH mouse model is essential for studying the underlying mechanism of the disease, testing therapeutic interventions, and evaluating efficacy of new drug candidates. This allows for close examination of the development of NASH, and how it responds to treatments in a controlled environment, only made possible through the NASH mouse model.
Variations of the Nash Mouse Model
Our mouse models are ideal for preclinical research, mirroring the progression of the NASH disease in humans, offering diverse applications in research, and translational value in preclinical findings and clinical outcomes, explore our wide range of NASH mouse model below:
Flexible and Customizable Analytical Assays
Track research progress with real-time updates to study tasks and milestones. Collect robust and meaningful data with the NASH mouse model.