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The Potential of Lead Discovery Services for Drug Discovery
Our lead discovery services will help accelerate and enhance the process of identifying potential therapeutic agents within your studies/research. It is a multidisciplinary approach that bridges the gap between target identification and the development of lead compounds
Lead discovery services have the capacity to rapidly screen vast compound libraries by using high-throughput screening and advanced computational methods, this will allow activity assessment of compounds against a specific target. Our lead discovery services can help accelerate the identification of lead compounds with the desired biological effects in your research.
Mechanism of Action (MoA) Studies in Lead Discovery
MoA studies explore compounds and their biological targets through advanced technologies that are available with our lead discovery services, providing multidisciplinary expertise, and analysis of binding kinetics, structural insights, and quantitative measurements. In exploring the complex mechanisms influencing compound interactions, we will be able to help guide your pathway towards drug discovery.
Biochemical Assays and Profiling
We have an extensive range of biochemical assays and profiling techniques for use, and methodologies that provide an idea of interactions between compounds and targets, explore enzyme activity assays to binding kinetics.
As part of our lead discovery services, MoA is crucial for validating the therapeutic potential of a compound and optimizing its safety and efficacity. Here is an overview of the process:
- Target Identification and Validation
- Compound Screening
- Hit Selection and Characterization
- MoA Elucidation
- Pathway Analysis
- Validation and Confirmation
- Optimization and Lead Development
- Preclinical Evaluation
Key Elements of our Lead Discovery Services
Compound Libraries for Targeted Lead Discovery: Pivotal in the early stages of drug discovery, the core component of our lead discovery services contributes to the success of lead optimization and identification of potential lead compounds. Carefully curated to incorporate a wide range of chemical structures, compound libraries in lead discovery services enhance your opportunity to find leads with high drug development potential.
Phenotypic Screening: Rather than targeting specific molecular targets, phenotypic screening departs from conventional molecular targets, and aims to evaluate the effects of potential compounds on cellular or organismal systems. This unbiased approach widens the scope of your drug discovery research, uncovering unexpected lead candidates, and will offer a fresh perspective on your studies.
Hit-to-lead Optimization: Another key element of our lead discovery services include Hit-to-Lead Optimization, by the identification of promising ‘hits’ or lead compounds, this process aims to enhance the potency, selectivity, and crucial attributes of lead compounds. Meaning your lead compounds will be refined and optimized to improve their drug-like properties and increase overall potential.
ADME-Tox Profiling: To ensure safety and efficacy of lead compounds our lead discovery services also include In Vitro and In Vivo testing covering aspects such as absorption, distribution, metabolism, excretion. Furthermore, toxicity profiles are conducted prior to the target compounds progressing further down the drug development pipeline.
Through our lead optimization you will have access to a wide range of pharmacology services that will help with the lead optimization of your drug candidate:
Lead Discovery Techniques and Services
Our lead discovery services encompasses a range of techniques:
High-throughput Screening (HTS)
Rapid evaluation of a vast array of compounds against biological targets is made possible through HTS. The use of automation and robotics enable the quick testing, and identification, of potential lead candidates with desired interactions. HTS through our lead discovery services can aid in accelerating drug discovery, by efficiently pinpointing compounds with therapeutic potential.
Fragment-Based Screening
Test small, low complexity, compound fragments against targets with fragment-based screening. Detection of fragments binding to targets will guide drug design, which offers precise starting points for optimization, supporting the development of potent and effective drug candidates.
Nuclear Magnetic Resonance (NMR)
NMR spectroscopy provides precise details on compound-target binding, supporting drug design and optimization. By determining molecular structures and their interactions, NMR is a technique that enhances the selection of potential drug candidates with tailored interactions for therapeutic efficacy.
Mass Spectrometry
Analyze the molecular masses and structures of target compounds, with Mass Spectrometry, as part of our lead discovery services. Aiding in the characterization of binding interactions, target engagement, and compound identification, providing insights into the effective development of targeted drug candidates.
