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HCT116 Mouse Xenograft Model
According to the American Cancer Society, colorectal cancer is the third-leading cause of cancer related deaths in men and the fourth-leading cause in women in the United States. Although increased screening has led to a decrease in death rates in older adults, death rates for adults under 55 continue to increase and prevalence of the disease still remains high.
Subcutaneous implantation of HCT116 cells lines into immunodeficient mice produces measurable tumors to evaluate the efficacy of novel therapeutic agents and immune modulation in a model of colorectal carcinoma.
Reproducible Growth
Subcutaneous implantation of cells allows for trackable tumor progression through caliper measurements. This is valuable for early intervention and evaluation of therapeutic treatments
Metastatic Potential
HCT116 cell line can also be used in a metastatic model to evaluate the progression of metastatic colonization with various therapeutic strategies.
Colorectal Carcinoma
Commonly Requested Endpoints
Histopathology
Our customizable histopathological analysis can help evaluate tumor microenvironments, track tumor progression and metastases and inform treatment decisions.
Flow Cytometry
Our flow cytometry expertise can help characterize tumor-infiltration T lymphocytes, identity immune biomarkers, and so much more.