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B16-F10 Mouse Model
The B16F10 murine model of melanoma is widely used in immuno-oncology, as this model enables preclinical evaluation of tumor growth, metastasis, and novel cancer therapeutics. The need for new and effective treatments is urgently growing as incident levels of melanoma, the deadliest form of skin cancer, have significantly increased over the last decade.
We have characterized the B16F10 mouse model of melanoma implanted subcutaneously as a flank model in C57BL/6 mice. This model can also be implanted orthotopically (intradermal) or intravenously to study lung metastases.
Fast Growing and Reproducible
Our B16F10 syngenetic mouse model tumors reflects late-stage tumorigenesis with mean tumor burden reaching euthanasia criteria within a month of inoculation allowing for efficient analysis of novel therapeutic agents.
Fully Characterized Model
This model can be used in an orthotopic (flank) application to study spontaneous metastases or injected intravenously to study lung metastases.
B16F10 Murine Melanoma
Commonly Requested Endpoints
Histopathology
Our customizable histopathological analysis can help evaluate tumor microenvironments, track tumor progression and metastases and inform treatment decisions.
Flow Cytometry
Our flow cytometry expertise can help characterize tumor-infiltration T lymphocytes, identity immune biomarkers, and so much more.