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4T1 Tumor Model
The 4T1 tumor model utilizes the 4T1 cell line, due to its ability to closely mimic the tumor microenvironment and the behavior of triple-negative breast cancer (TNBC), the 4T1 tumor model is ideal for preclinical TNBC studies.
Triple-negative breast cancer constitutes a significant portion of breast cancer cases that are reported per year worldwide. Although diagnosis of early-stage cancer benefits significantly from established treatments, therapeutics are in limited availability for advanced metastatic varieties of breast cancer, one of the most prevalent forms of cancer in women throughout the United States.
We have characterized the 4TI mouse model of mammary gland cancer expressed as a flank model in BALB/c mice for study of primary tumors and late-stage metastatic disease. Our model is easily adaptable to suit your therapeutic inquiries and downstream analyses.
Fast Growing and Reproducible
The fast-growing tumors in our 4TI syngeneic model allow for efficient and reproducible analysis of therapeutic agents.
Metastatic Potential
The 4TI cell line spontaneously metastasizes in mice, spreading to the lung, liver, lymph nodes, brain and bone, providing a viable platform for late-stage drug discovery.
4TI Mouse Mammary Cancer Model
4T1 is highly tumorigenic, highly invasive, and spontaneously metastasized from the primary tumor site that can be investigated in a flank or orthotopic model.
Commonly Requested Endpoints
Histopathology
Our customizable histopathological analysis can help evaluate tumor microenvironments, track tumor progression and metastases and inform treatment decisions.
Flow Cytometry
Our flow cytometry expertise can help characterize tumor-infiltration T lymphocytes, identity immune biomarkers, and so much more.