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Chronic and Sub Chronic Toxicity Studies
Explore our broad catalog of capabilities to support chronic and sub-chronic toxicity studies. From discovery through in vivo pharmacology, our team provides the highest quality data to guide safety decisions and define your drug development pipeline.
Understanding the long-term effect of your drug on overall physiology and behavior is a critical component in successful driving a product to the clinic.
Sub-chronic Toxicity Studies
Typically 28-90 days, sub-chronic toxicity studies are designed to detect adverse effects over a moderate period.
Chronic Toxicity Studies
Spanning 90 days to over a year, chronic toxicity aims to identify long-term, cumulative, and delayed onset adverse effects that may not show up in a shorter study.
Routes of Administration
The chosen route of administration is critical for meaningful toxicity data. Long-term exposure must occur in the context of relevant physiology to inform real effects.
Capabilities and Services Summary
High Animal Welfare Standard
Our technical and veterinary team adhere to the highest standards for animal care and welfare. Not only is our vivarium an AAALAC accredited facility with an in-house IACUC, but our team goes the extra mile to give the animals the best level of care. We have a robust positive reinforcement training program as well as industry-leading housing and enrichment standards.
In-House Capabilities
Ichor serves as a one-stop-shop for many in vivo study needs, and we use the most state-of-the-art equipment for the work we perform. Our team can assess neurobehavioral endpoints, perform almost every blood collection or dosing technique, as well as a myriad of ophthalmology techniques, and more. You can be confident you’re getting the best there is to offer.
Experts in the Unconventional
Ichor is your ideal partner for unconventional ideas and studies. Before spending exorbitant amounts of money on a GLP study, consider partnering with our team to run a DRF or exploratory study so you can begin your large-scale GLP studies with confidence.
Frequently Asked Questions
Optimal preclinical study design is essential for successful drug development. Let our vast experience guide your thinking.
Sub-chronic and sub-acute toxicity relate to adverse effects that result from repeated exposure to a substance between 28 and 90 days. This is longer than the acute phase but shorter than the chronic phase.
Treated animals are observed for behavioral abnormalities, blood chemistry results, and weight changes for the duration of the study. Upon completion, necropsy analysis analyzes organ physiology and can hone in on specific pathobiology if needed.
Chronic toxicity studies expand upon sub-chronic toxicity studies by extending for several months longer or even years longer! This is to identify subtle changes that would escape detection in shorter studies.
As a lifespan and aging company, Ichor has specialized capabilities in housing for animals that require highly-specific standards of care. Our expertise in aged animals enables us to perform nuanced animal work at a high level.