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Drug Tolerability Studies
Tolerability in drug toxicology is an important consideration when considering clinical application. The ability to manage therapeutic intervention and patient compliance is critical when proposing novel drugs to regulatory authorities.
The tolerability of a medical product is the degree to which symptomatic and non-symptomatic adverse events associated with the product’s administration affect the ability or desire of the patient to adhere to the dose or intensity of therapy.
Maximum Tolerated Dose (MTD)
The MTD is defined by the highest amount of a substance that can be administered without affecting safety or toxicity.
MTD and Efficacy
Ideally, the MTD is exactly that: maximum. Excessive dosing without benefit is always avoided in studies at Ichor.
Drug Toxicology and Efficacy
With our robust drug toxicology and efficacy capabilities, you can ensure that tolerability considerations are at the forefront of your program.
Capabilities and Services Summary
High Animal Welfare Standard
Our technical and veterinary team adhere to the highest standards for animal care and welfare. Not only is our vivarium an AAALAC accredited facility with an in-house IACUC, but our team goes the extra mile to give the animals the best level of care. We have a robust positive reinforcement training program as well as industry-leading housing and enrichment standards.
In-House Capabilities
Ichor serves as a one-stop-shop for many in vivo study needs, and we use the most state-of-the-art equipment for the work we perform. Our team can assess neurobehavioral endpoints, perform almost every blood collection or dosing technique, as well as a myriad of ophthalmology techniques, and more. You can be confident you’re getting the best there is to offer.
Experts in the Unconventional
Ichor is your ideal partner for unconventional ideas and studies. Before spending exorbitant amounts of money on a GLP study, consider partnering with our team to run a DRF or exploratory study so you can begin your large-scale GLP studies with confidence.
Frequently Asked Questions
Optimal preclinical study design is essential for successful drug development. Let our vast experience guide your thinking.