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Toxicology Studies
Ichor Life Sciences provide a range of toxicology studies and services to support drug development, with a focus on in vivo toxicity testing, small molecule, biologics, and cell-therapy programs. Our detail orientated staff are dedicated to conducting and advising on both standard and novel toxicology studies.
Our Toxicology Services
Acute Toxicology and Dose Finding Studies
Acute toxicity studies are conducted in order to understand the potential short-term adverse effects of a drug, they involve the administration of a single, or limited, dose within a 24 hour period. In assessing the impact, and measuring the lethal dose 50 (LD50), of the drug or article, acute toxicology and dose finding studies will generate valuable data that aids in establishing safe exposure levels.
Do you need help in characterizing the toxicity of your test article, and determining the appropriate dose? We can investigate its adverse effects, and provide important information regarding the LD50, and the therapeutic index of your test article.
Subchronic/Chronic Toxicology Studies
Subchronic and Chronic Toxicology studies assess whether there is a development of adverse effects as a result of long term exposure to the test article. Subchronic toxicity testing assesses the adverse effects of a substance after repeated administration, for no longer than a period of 10% of the animals average life span. Chronic toxicology studies however involve prolonged exposure to the substance, often lasting two years or more, evaluating the long-term effects and carcinogenicity of the substance.
We have a team of experts devoted to exploring the long-term effects of substances, and providing you with comprehensive data to inform important decisions about the safety of your test article.
Investigative Services
We offer many services to aid in your investigation including gross examination, complete blood counts, clinical chemistries, behavior tests, tissue histopathology, and many more.
Ocular Toxicology
Interested in ocular toxicity? We have large animal capabilities and a dedicated ophthalmic team that offers tonometry (IOP) evaluation, electroretinography (ERG), enhanced microscopic evaluation, ocular histopathology, ocular and systemic tissue distribution, and more!
Frequently Asked Questions
General toxicology studies evaluate the toxicity of substances, providing a risk assessment of the test article before it can be able to be marketed. These studies are vital in not only safeguarding human health, but also contributes to environmental protection, guiding regulatory decisions, and aids product safety and development.