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Genetic Modulation Services
From siRNA knockdown to classic transfections and viral gene delivery, our genetic modulation solutions integrate seamlessly with validated cell and tissue assays, delivering robust analysis of rich datasets to generate reliable results that advance therapeutic discovery, support development, and accelerate fundamental research.
Discover Our Comprehensive Genetic Modulation Services
We provide comprehensive solutions, from gene design and vector packaging to cell delivery and molecular readouts, leveraging our diverse scientific expertise to deliver high-quality data and actionable results from flexible models.
Our Workflows Include the Following Services
Ichor takes your idea from concept to data with versatile and customizable workflows without compromising scientific rigor.
Discover Our Featured Telomere Length Analysis by quantitative PCR Assay
We approach challenging samples, such as blood, with optimized nucleic acid extraction workflows to ensure high-quality DNA recovery. In this lifespan extension study, genomic DNA from mouse blood was analyzed using a quantitative PCR assay normalized to a single-copy reference gene to quantify telomere length per chromosome end. Results revealed differences in telomere shortening rates between treatment and vehicle groups, offering insights into treatment effects on cellular aging and genome stability.
Custom Assay Example: Analyze Target via Genetic Modulation
Quantifying Target Degradation via Genetic Modulation with Complimentary Assays
Using transient vs stable transfection, time-course analysis reveals distinct degradation kinetics, enabling precise evaluation of target stability and in-cell efficiency of degrader–target interactions in K-562 cells with optimized gene delivery protocols.
Confirm Transfected Target Degradation by Western Blot
Western blot analysis confirms time-dependent loss of the transfected target in K-562 cells, validating transient vs stable transfection data and supporting in-cell assessment of degrader–target interaction efficiency.