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Genetic Modulation Services
From siRNA knockdown to classic transfections and viral gene delivery, our genetic modulation solutions integrate seamlessly with validated cell and tissue assays, delivering robust analysis of rich datasets to generate reliable results that advance therapeutic discovery, support development, and accelerate fundamental research.
Discover Our Comprehensive Genetic Modulation Services
We provide comprehensive solutions, from gene design and vector packaging to cell delivery and molecular readouts, leveraging our diverse scientific expertise to deliver high-quality data and actionable results from flexible models.
Our Workflows Include the Following Services
Ichor takes your idea from concept to data with versatile and customizable workflows without compromising scientific rigor.
We work with you to understand your project needs and design optimized gene sequences tailored for your application, ensuring high expression efficiency, compatibility with your chosen delivery system, and relevance to downstream functional readouts.
We regularly extract nucleic acids from tissue, blood, and cell samples, as well as specialized materials such as patient bandages, with comprehensive quantity, quality, and purity assessments for downstream analyses.
We validate models and analyze target and small-molecule response profiles through comparative transcript analysis, identifying significant changes in gene activity across samples or conditions.
We support both short-term (transient) and stable gene delivery and expression, utilizing optimized protocols to maximize efficiency, reproducibility, and alignment with your project goals and downstream assays.
Quantification of gene expression with multiplex quantitative PCR assay capability (up to 4 targets in a single well) and quality control, using sensitive, validated methods to assess activity under different experimental conditions.
Discover Our Featured Telomere Length Analysis by quantitative PCR Assay
We approach challenging samples, such as blood, with optimized nucleic acid extraction workflows to ensure high-quality DNA recovery. In this lifespan extension study, genomic DNA from mouse blood was analyzed using a quantitative PCR assay normalized to a single-copy reference gene to quantify telomere length per chromosome end. Results revealed differences in telomere shortening rates between treatment and vehicle groups, offering insights into treatment effects on cellular aging and genome stability.
Custom Assay Example: Analyze Target via Genetic Modulation
Quantifying Target Degradation via Genetic Modulation with Complimentary Assays
Using transient vs stable transfection, time-course analysis reveals distinct degradation kinetics, enabling precise evaluation of target stability and in-cell efficiency of degrader–target interactions in K-562 cells with optimized gene delivery protocols.
Confirm Transfected Target Degradation by Western Blot
Western blot analysis confirms time-dependent loss of the transfected target in K-562 cells, validating transient vs stable transfection data and supporting in-cell assessment of degrader–target interaction efficiency.
Frequently Asked Questions
These are valuable techniques for molecular drug discovery, but the choice depends on your experimental goals. Transient transfection enables short-term gene expression for rapid testing, while stable transfection mammalian cells integrates genetic material into the host genome for long-term, consistent expression in mammalian cells. Ichor team supports and has extensive experience with both types of transfections even in hard to transfect cell types like HSCs.
Ichor team commonly handles cell pellets, various animal tissues, blood, and unconventional patient-derived samples, with quantity, quality, and purity assessment.
Absolutely, our team of molecular biology experts will collaborate with you to design gene sequences, select delivery methods, and develop functional readouts aligned with your research or therapeutic development goals.
Yes. We serve as a one-stop shop for preclinical genetic modulation work, providing solutions from gene design and vector packaging to delivery in your chosen cell system, followed by molecular and functional assay readouts.