Dr. Moody presented on a platform technology to treat gut aging that is being developed by Auctus Biologics, an Ichor portfolio company. Dr. Moody discussed that perturbations in gut health may significantly contribute to aging and age-related diseases, which may include autoimmune disease, “leaky gut”, nutritional and metabolic changes resulting from reduced microbial diversity, and disturbance of the gut/brain axis, which may contribute to age-associated neurodegeneration.
Dr. Moody described Auctus Biologics’ development of “ribobodies,” a new therapeutic modality that may be useful to study and treat gut aging. A ribobody is a small, gut-stable compound that mimics antibodies.
Left: IgG antibody
Each is composed of protein scaffold (blue) and a binding interface (pink).
While antibodies have been extraordinarily beneficial in research and the clinic, their use in the gut is limited because they are rapidly degraded by the gastrointestinal system. Ribobodies are more robust and do not significantly degrade, allowing for broad applications in research and medicine, particularly within the gut.
Last year, Ichor raised $1.5MM to develop this platform, and published their findings in the peer-reviewed journal “ACS Biochemistry.”