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Intraocular Pressure (IOP)
Ichor offers rodent and rabbit IOP models for your products using the most robust positive reinforcement training (PRT) program and reproducible clinical comparator positive controls. Let us help you design the most optimal study design for your product based on your mechanism of action to give you the best results.
We provide you with the most accurate IOP measurements and drug delivery. Our model includes a training program to acclimate the animals to take IOP measurements without the need of anesthetics that are known to introduce variables into your results. Our stress free animals provide optimal results. Need additional tissue collections? We also include aqueous humor collections for rodents and large animals.
Tonometer Measurements
For rodents we conduct our studies using the Tonolab®, and for large animals the Tonovet®
Topical Dosing Techniques
Included with the PRT is acclimation to topical dosing.
Intraocular drug delivery
If necessary, intracameral injections are available for rodents and large animals.
IOP Results
ROCK Inhibitors available as a positive control
Through our validation process we investigated the IOP lowering effects with ROCK inhibitors should you need a positive control comparator. Prior to enrollment we include validation tests of our controls before dosing is initiated.
Latanoprost available as positive control for rats
We include a clinical comparator as our positive control for our standard rat IOP model. Like the ROCK inhibitor model, a validation test is included prior to study initiation to ensure your results will be as accurate as possible.
Why do we include PRT?
Stress and the use of anesthetics can have negative impacts on the intraocular pressure. Animals go through a training program to be as comfortable as possible.