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SCLC Xenograft Mouse Model
Lung cancer is the leading cause of cancer deaths worldwide. It’s characterized by two main types – small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). SCLC accounts for roughly 10-15% of lung cancers but has a disproportionate number of deaths and high relapse rates, making the study of novel treatments and therapeutics critical.
We have characterized models of small cell lung cancer (SCLC) with subcutaneous implantation of immunodeficient mice that produces measurable tumors to evaluate the efficacy of novel therapeutic agents and immune modulation.
COR-L95
NCI-H1963
NCI-H1836
COR-L279
Reproducible Growth
Subcutaneous implantation of cells allows for trackable tumor progression through caliper measurements. This is valuable for early intervention and evaluation of therapeutic treatments.
Metastasis Potential
SCLC often spreads to other parts of the body, including the lymph nodes, liver, bones, adrenal glands and brain, allowing for the study of metastatic progression various therapeutic strategies.
B16F10 Murine Melanoma
Commonly Requested Endpoints
Histopathology
Our customizable histopathological analysis can help evaluate tumor microenvironments, track tumor progression and metastases and inform treatment decisions.
Flow Cytometry
Our flow cytometry expertise can help characterize tumor-infiltration T lymphocytes, identity immune biomarkers, and so much more.