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Angiotensin II Induced Hypertension
Hypertension impacts almost 50% of adults in the United States. A reliable mouse model is key to investigating mechanisms and treatments for this very prevalent disease. The angiotensin II (AngII) infusion provides that and is a staple cardiovascular disease model at Ichor.
AngII increases blood pressure by causing vasoconstriction and triggering aldosterone release. It plays a key role in hypertension and cardiac disease. Utilizing a subcutaneous infusion pump, delivering AngII to mice creates a consistent hypertensive state that leads to translatable clinical changes.
Efficient induction
Animals and pumps are readily available, and our trained surgical staff are always ready to get going. With acute remodeling present within 14 days, we can quickly iterate your cardiovascular drug development needs.
Precise and consistent
Subcutaneous implantation of an osmotic micro infusion pump that slowly releases a precise dose of Angiotensin II is a premium model of hypertension induced cardiovascular disease. Constant infusion limits variability, helping drive clean results.
Clearly defined endpoints
Histopathology produces a comprehensive workup to assess vascular inflammation, fibrosis, and remodeling in your tissues of interest. Heart and aortic thickness are primary readouts demonstrating both model and drug efficacy.
Histology of primary tissues such as the aorta, heart, and kidneys display clear inflammation and remodeling secondary to the hypertensive state.
Immunohistochemistry is also a powerful tool to evaluate the inflammatory properties of remodeling that occurs within the aorta or other tissues.