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Bioanalytical Mass Spectrometry
Our Liquid Chromatography–Mass Spectrometry (LC/MS) services provide a comprehensive suite of capabilities including method development, quantitative bioanalysis, and pharmacokinetic profiling. Whether you are measuring small molecules or peptides, our LC/MS expertise supports you in advancing discovery, preclinical development, and translational research with precision and reliability.
Liquid Chromatography–Mass Spectrometry (LC/MS) is a powerful analytical technique that combines the separation capabilities of liquid chromatography with the sensitive detection of mass spectrometry. LC/MS is used to identify, quantify, and characterize molecules within complex biological and chemical mixtures.
The LC/MS procedure begins by separating sample components through liquid chromatography, followed by ionization and mass analysis to detect each molecule according to its mass-to-charge ratio (m/z). This enables precise measurement of both known and unknown compounds, ranging from small molecules and peptides to metabolites and impurities.
We utilize a Thermo TSQ Quantis triple quadrupole mass spectrometer for high-sensitivity quantitative analysis, alongside a single quadrupole instrument for robust method development and routine assays. Together, these systems provide a comprehensive platform for bioanalysis, pharmacokinetics, metabolite profiling, and compound characterization.
Versatility Across Sample Types
From plasma and tissue homogenates to formulations and environmental samples, our LC/MS platforms adapt seamlessly to diverse applications.
Structural & Molecular Insights
Combine LC separation with MS/MS fragmentation to accurately identify metabolites, impurities, and molecular structures with high resolution.
High Sensitivity Quantitation
If promising conditions are not identified with the intact preparations of proteins, then the protein can be modified by either in situ proteolysis or lysine methylation. The modified protein can then be screened.
Selective & Specific Detection
Triple Quadrupole multiple reaction monitoring (MRM) ensures unmatched selectivity, separating target analytes from complex backgrounds with confidence and clarity.
Reproducible Bioanalysis Data
We produce validated workflows to deliver consistent, high-quality bioanalytical data to accelerate drug discovery, PK/PD studies, and regulated bioanalysis.
Featured Capabilities
Our preclinical ophthalmic research team utilizes industry-best equipment to conduct studies. Quality equipment for quality results.
Your Results Await
Our specialized LC/MS service is designed to meet your unique research needs. Our team of scientists works closely with you to develop customized methods, whether building assays from scratch, adapting literature protocols, or optimizing existing workflows. From experimental design through data analysis, we emphasize collaboration at every stage, ensuring our analysis platforms deliver results aligned with your goals. This partnership-driven approach guarantees that every aspect of our LC/MS service supports your research from start to finish.
LC/MS is a state-of-the-art analytical technique for characterizing, quantifying, and identifying molecules across a wide range of biological and chemical systems. Our LC/MS services leverage the Thermo TSQ Quantis triple quadrupole and complementary single quadrupole platforms to provide robust, sensitive, and high-throughput workflows.
- High-sensitivity quantitative analysis – Accurate, reproducible quantitation of small molecules, peptides, and biomarkers in complex matrices
- Pharmacokinetic (PK) & pharmacodynamic (PD) studies – Comprehensive profiling of drug absorption, distribution, metabolism, and elimination
- Impurity & stability testing – Sensitive detection of degradation products, contaminants, and formulation stability markers
- Method development & validation – Custom LC/MS method design, optimization, and regulatory-compliant validation for preclinical and clinical studies
- Biomarker discovery & validation – Quantitative support for translational research and clinical biomarker programs