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Intraocular Pressure Models
Our rodent intraocular pressure (IOP) reduction models test investigational products aimed at alleviating intraocular hypertension. Select from Latanoprost control or the Rho-kinase (ROCK) control based on your mechanism of action.
Our rodent models include robust positive reinforcement training (PRT) prior to study initiation. PRT removes study variables by eliminating anesthetic use and keeps animals stress free. This allows for the most accurate IOP measurements.
Positive Reinforcement Training (PRT)
Our animals undergo PRT so anesthetics are not required and animals remain stress free for accurate results.
Tonometer Measurements
For rodents we conduct our studies using the Tonolab® and for large animals the Tonovet®.
Topical Dosing Techniques
Included with the PRT is acclimation to topical dosing.
Intraocular Drug Delivery
If necessary, intracameral injections are available for rodents and large animals.
Intraocular Pressure Models
Glaucoma is one of the leading causes of blindness worldwide and by providing our IOP models, our goal is to help get ahead of ocular hypertension before the cascade of the disease. Here we provide you with the option for testing against two separate controls. Depending on your mechanism of action you can select from the Latanoprost control or the Rho-kinase (ROCK) control. Our IOP reduction models give you reliable IOP measurements in head-to-head comparisons of these controls.
Latanoprost
Latanoprost has a known profile comprising a hypertensive then subsequent hypotensive phase and serves as a control when testing new therapies. It is commonly used as a positive control in rats.
Rho-Associated Kinase (ROCK) Inhibitors
ROCK inhibitors relieve intraocular hypertension by increasing the outflow of aqueous humor and reducing scleral venous pressure. They are an emerging positive control for assessing new therapies.