Skip to content
Macrophage Response to Biomaterials in Wound Healing
Ichor Life Sciences delivers specialized preclinical evaluation of biomaterials, assessing M1 vs M2 macrophage response in validated cell models to optimize biocompatibility, reduce inflammation, and accelerate regenerative outcomes.
Traditional immunotoxicology focuses on lymphocyte subsets, but biomaterials require innate immunity assays. M1 vs. M2 macrophage polarization testing reveals biocompatibility and pro-healing potential: faster closure, reduced scarring, enhanced regeneration.
Preclinical Testing at Three Wound Healing Phases
Inflammatory Phase Cytokine & Macrophage Panels
We offer quantitative standard inflammatory panel + M1 vs M2 polarization assays quantify pro-inflammatory and pro-healing responses with biomaterials.
Proliferative Phase Scratch Wound & Cell Migration
Ichor runs optimized primary cell (fibroblast and endothelial cells) models with real-time Incucyte scratch assays in classic/inflamed wound models.
Remodeling Phase MMP Activity & Tissue Remodeling
In addition classic in vitro wound healing readouts, we commonly perform MMP activity profiling plus molecular endpoints (collagen deposition, gene expression, histology) to evaluate ECM remodeling and scar resolution in long-term studies.
M1 vs M2 macrophage markers
Ichor quantifies 10+ key cytokines (TNF-α, IL-6, IL-1β, IL-10, IL-12p70, IL-23, CCL17/TARC, CXCL10/IP-10, etc.) via bead array in pg/mL ranges, enabling precise M1 pro-inflammatory vs. M2 pro-healing macrophage polarization analysis under biomaterials in wound healing models.